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FLASH GENE
Symbol STMN3 contributors: mct/shn - updated : 03/03/2012
HGNC name stathmin-like 3
HGNC id 15926
Location 20q13.33      Physical location : 62.271.060 - 62.284.780
Synonym name
  • SCG10-like protein
  • SCG10-like-protein
  • stathmin-3
  • Synonym symbol(s) SCLIP
    DNA
    TYPE functioning gene
    STRUCTURE 13.72 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure two putative neuron-restricted silencer elements (NRSEs)
    MAPPING cloned Y linked N status provisional
    Map cen - D20S171 - D20S173 - STMN3 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2255 21 180 Neuron specific 1998 9603203
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiens
    Digestiveintestinelarge intestinecolon moderately Homo sapiens
     liver   lowly Homo sapiens
     salivary gland   lowly Homo sapiens
    Endocrineadrenal gland   moderately Homo sapiens
     pancreas   moderately Homo sapiens
     thyroid   highly Homo sapiens
    Lymphoid/Immunespleen   moderately Homo sapiens
     thymus   highly Homo sapiens
    Nervousbrainhindbraincerebellum highly Homo sapiens
     brain   highly Homo sapiens
     spinal cord   highly Homo sapiens
    Reproductivefemale systemovary  moderately Homo sapiens
     female systemplacenta  moderately Homo sapiens
     female systemuterus  moderately Homo sapiens
     female systembreast  moderately Homo sapiens
     male systemtestis  moderately Homo sapiens
     male systemprostate  moderately Homo sapiens
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately Homo sapiens
    Muscularstriatumskeletal lowly Homo sapiens
    Nervous   specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • fetal brain, liver (
  • strongly expressed in Purkinje cells during cerebellar development and accumulates in their dendritic processes at a critical period of their formation and outgrowth
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal likely involved in membrane attachment
  • a C terminal stathmin like domain
  • HOMOLOGY
    interspecies ortholog to Stmn3, Mus musculus
    ortholog to Stmn3, Rattus norvegicus
    intraspecies homolog to SCG10
    Homologene
    FAMILY stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • at least partially associated to the Golgi apparatus
  • colocalized to the Golgi apparatus of chromaffin cells and shared localization with CHGA as it transited the Golgi
  • basic FUNCTION
  • able to depolymerize interphase microtubules when overexpressed
  • acts as microtubule destabilizers
  • playing a role in differentiated neurons
  • regulator of axonal branching in hippocampal neurons, and having a function in axonal morphogenesis
  • implicated in the development and functional regulation of various organs, most notably the nervous system
  • participate in the control of microtubule dynamics and may be involved in the control of neuronal differentiation
  • STMN2 and STMN3, interact with CHGA, share partial colocalization in the Golgi apparatus, and may be necessary for typical transmitter storage and release from chromaffin cells
  • crucial for both the formation and proper development of Purkinje cell dendritic arbors
  • novel and specific factor that controls the early phases of Purkinje cell dendritic differentiation during cerebellum development
  • palmitoylation of stathmins 3 likely occurs at the Golgi and is crucial for its specific subcellular localization and trafficking (
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text signal transduction and regulation of microtubule dynamics
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel RASGRF1-interacting protein, and influences the signaling properties of RASGRF1
  • CHGA and STMN2 (
  • STAT3 (
  • DHHC3, DHHC7, DHHC15, and DHHC17 (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS