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FLASH GENE
Symbol TNFSF4 contributors: mct - updated : 09-02-2008
HGNC name tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
HGNC id 11934
Location 1q25      Physical location : 173.152.870 - 173.176.471
Synonym name
  • OX-40 ligand
  • CD134 ligand
  • glycoprotein 34 kd
  • OX40 antigen ligand
  • tax-transcriptionally activated glycoprotein 1 (34kD)
  • Synonym symbol(s) OX40L, TXGP1, GP34, CD134L, CD252, OX-40L
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 23.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - DNM3 - PIGC - C1orf9 - FASLG - TNFSF18 - TNFSF4 - PRDX6 - KLHL20 - SERPINC1 - MRPS14 - TNN - TNR - qter
    Authors Wang(05)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3510 - 183 - Liu (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunelymph node    
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    an extracellular C terminus
    conjugated GlycoP
    mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfsf4
    Homologene
    FAMILY tumor necrosis factor (ligand) superfamily
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane glycoprotein (TM1)
    basic FUNCTION
  • playing a role in regulating immune responses
  • involved in T cell antigen-presenting cell (APC) interactions
  • required on activated CD4+ and CD8+ T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein TNFRSF4 ligand (with its receptor directly mediate adhesion of activated T cells to vascular endothelial cells)
    cell & other
    REGULATION
    induced by on activated CD4+ and CD8+ T cells, and its expression is enhanced by TGF-beta1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    predisposes to SLE either by quantitatively augmenting T cellAPC interaction or by influencing the functional consequences of T cell activation via TNFRSF4
    Susceptibility
  • to atherosclerosis, myocardial infarction
  • to systemic lupus erythematosus (SLE)
  • Variant & Polymorphism SNP
  • SNP increasing the risk of atherosclerosis, myocardial infarction
  • Candidate gene target for atherosclerosis therapy
    Marker
    Therapy target
    ANIMAL & CELL MODELS