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FLASH GENE
Symbol TSC22D4 contributors: mct/npt - updated : 08/11/2008
HGNC name TSC22 domain family, member 4
HGNC id 21696
Location 7q22.1      Physical location : 100.064.143 - 100.076.902
Synonym name
  • TSC-22-like
  • transforming growth factor (TGF)-beta-stimulated clone 22 domain 4
  • Synonym symbol(s) THG-1, THG1, Thg-1pit
    DNA
    TYPE functioning gene
    STRUCTURE 12.76 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2399 41 395 - Fiorenza (2001)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     pancreas exocrine   lowly
    Endocrineneuroendocrinepituitary  lowly
    Lymphoid/Immunespleen   highly
     thymus   predominantly
    Reproductivefemale systemovary  lowly
    Skin/Tegumentskin   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Tsc22d4
    Homologene
    FAMILY
  • TSC-22/Dip/Bun family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor
  • may be involved in adaptation of renal cells to hypertonicity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming homodimer or heterodimer
  • can form an heterodimer with TSC22D1
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TSC22D1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS