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FLASH GENE
Symbol UBE2Q2 contributors: - updated : 13-10-2007
HGNC name ubiquitin-conjugating enzyme E2Q (putative) 2
HGNC id 19248
Location 15q24.2      Physical location : 76.135.621 - 76.193.388
Synonym name ubiquitin-conjugating enzyme with implantation site-specific expression
Synonym symbol(s) LOC92912, UBCI
DNA
TYPE functioning gene
STRUCTURE 57.00 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineparathyroid   highly
Reproductivefemale systemuterus  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RWD domain
  • a coiled-coil
  • an E2 ubiquitin conjugating enzyme domain
  • HOMOLOGY
    intraspecies homolog to UBE2Q1
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functions may be linked with the cytoskeleton
  • involved in the response to microtubule inhibiting agents rather than performing a more general function in mitosis
  • normally functions to antagonize an early mitotic checkpoint
  • my be having a specific function in implantation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hypopharyngeal tumours
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target target for cancer therapeutics (inhibition of UBE2Q2 protein function may be useful in the treatment of malignancies)
    ANIMAL & CELL MODELS