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FLASH GENE
Symbol UBE2W contributors: mct - updated : 20-08-2012
HGNC name ubiquitin-conjugating enzyme E2W
HGNC id 25616
Location 8q21.11      Physical location : 74.702.841 - 74.791.110
Synonym name
  • ubiquitin carrier protein W
  • ubiquitin-conjugating enzyme 16
  • Synonym symbol(s) UBC-16, UBC16, hUBC-16
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 88.27 kb     6 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4024 - 151 - 2011 21229326
    7 - 4057 - 162 - 2011 21229326
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • could regulate FANCD2 monoubiquitination by mechanisms different from UBE2T or HHR6
  • may provide an additional regulatory step in the activation of the FA pathway
  • UBE2W and ATXN3, participate in initiating, regulating, and terminating the STUB1 ubiquitination cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to FANCL, and the PHD domain is both necessary and sufficient for this interaction in mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS