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FLASH GENE
Symbol WNT16 contributors: mct/npt - updated : 28-03-2015
HGNC name wingless-type MMTV integration site family, member 16
HGNC id 16267
Location 7q31.31      Physical location : 120.965.420 - 120.981.157
Synonym name protein Wnt-16
DNA
TYPE virus associated
STRUCTURE 15.74 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence alternative promoter
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two transcript variants diverging at the 5' termini and produced by separate promoters
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2894 - 355 - 2009 19951988
  • WNT16a (short form)
  • difference in the 5' terminus including 5' UTR and the coding region for the N-terminus (1st exon)
  • 4 initiation site 3132 40.7 365 expressed only in pancreas 2009 19951988
  • WNT16b
  • an hydrophobic signal peptide and many conserved cysteine residues
  • upregulated in basal cell carcinomas compared with normal skin
  • activated the Jun-N-terminal kinase cascade (may be involved in the activation of a non-canonical WNT signalling pathway)
  • activates keratinocyte proliferation possibly via a beta-catenin-independent non-canonical WNT transduction pathway
  • is a new marker of senescence that regulates TP53 activity and the PI3K/AKT pathway and is necessary for the onset of replicative senescence
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Nervousbrain    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans W08d2.1
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text associated with the extracellular matrix
    basic FUNCTION
  • ligand for members of the frizzled family of seven transemembrane receptors
  • plays an important role in leukemogenesis, raising its therapeutic interest
  • is an important determinant of cortical bone thickness (CBT) and bone mineral density (BMD), bone strength, and risk of fracture
  • is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/CTNNB1 pathway
  • regulates the somitic expression of two Notch ligands, deltaC (dlc) and deltaD (dld), whose combined function is required for HSC fate
  • antagonistic role for WNT16 in the chondrogenic transformation of vascular smooth muscle cells (VSMCs)
  • attenuates TGFB-Induced chondrogenic transformation in vascular smooth muscle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
    Susceptibility
  • to osteoporotic fractures
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS