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FLASH GENE
Symbol YOD1 contributors: mct - updated : 06-06-2017
HGNC name YOD1 deubiquitinase
HGNC id 25035
Location 1q32.1      Physical location : 207.217.193 - 207.224.422
Synonym name
  • otubain
  • Synonym symbol(s) OTUD2, DUBA8, PRO0907
    DNA
    TYPE
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY ovarian tumor family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • is a deubiquitinating enzyme that associates with VCP to facilitate protein dislocation from the ER
  • VCP and YOD1 are required in the downstream events of substrate deglycosylation and proteasomal degradation (
  • is a novel regulator of Hippo pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VCP/p97 cooperates with YOD1, UBXN6 and PLAA to drive clearance of ruptured lysosomes by autophagy
  • YOD1 is a novel interactor of TRAF6 (antagonizes TRAF6/p62-dependent IL1 signaling to NFKB1)
  • mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP/TAZ level
  • YOD1 stabilizes ITCH and facilitates ITCH-mediated LATS1/2 ubiquitination and degradation, which results in increased YAP/TAZ level
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    potential therapeutic target for liver cancer
    ANIMAL & CELL MODELS