basic FUNCTION
| may be involved in transcriptional regulation |
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nuclear transcriptional repressor whose repressive activity depends on its association with HDAC1 and -2 |
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directly represses Patched1 (PTCH1) expression and likely functions to repress the hedgehog response in cells |
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role in controlling both PTCH1 basal expression and cellular response to Hh signaling |
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can function as a transcriptional repressor, and its repressive activity is dependent on the KRAB A domain |
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normal function of ZNF431 may be to control Hh responsiveness within physiological range for signal transduction |