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FLASH GENE
Symbol ZNF431 contributors: mct - updated : 01-12-2009
HGNC name zinc finger protein 431
HGNC id 20809
Location 19p12      Physical location : 21.324.839 - 21.368.805
Synonym symbol(s) KIAA1969, DKFZp313E0830
DNA
TYPE functioning gene
STRUCTURE 43.92 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3861 - 576 - 2011 2117753
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 C2H2-type zinc fingers
  • one KRAB domain
  • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • nuclear localization of ZNF431 protein is consistent with its role as a transcription factor
  • basic FUNCTION
  • may be involved in transcriptional regulation
  • nuclear transcriptional repressor whose repressive activity depends on its association with HDAC1 and -2
  • directly represses Patched1 (PTCH1) expression and likely functions to repress the hedgehog response in cells
  • role in controlling both PTCH1 basal expression and cellular response to Hh signaling
  • can function as a transcriptional repressor, and its repressive activity is dependent on the KRAB A domain
  • normal function of ZNF431 may be to control Hh responsiveness within physiological range for signal transduction
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • PTCH1 is a direct transcriptional target of ZNF431
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS